1.- Minecraft - Over 300 million copies.
2.- Grand Theft Auto V - Over 210 million copies.
3.- Tetris (EA) - 100 million copies.
4.- Wii Sports - 82.9 million copies.
5.- Red Dead Redemption 2 - 77 million copies.
6.- PUBG: Battlegrounds - 75 million copies.
7.- Mario Kart 8/Deluxe - Around 60 million copies (combined).
8.- Super Mario Bros. - 58 million copies.
9.- Human: Fall Flat - 50 million copies.
10.- The Witcher 3: Wild Hunt - 50 million copies.
11.- Pokemon Red/Green/Blue/Yellow - 47.5 million copies.
12.- Terraria - 44.5 million copies.
13.- Wii Fit/Plus - 43.8 million copies.
14.- Animal Crossing: New Horizons - 43.38 million copies.
15.- Tetris (Nintendo) - 43 million copies.
16.- Pac-Man - 42 million copies.
17.- Mario Kart Wii - 37.38 million copies.
18.- Wii Sports Resort - 33.14 million copies.
19.- New Super Mario Bros. - 30.8 million copies.
20.- The Elder Scrolls V: Skyrim - 30 million copies.